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Numbness persists in patient after four years of injections

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DEAR DR. ROACH: I was in excellent health until December 2020, when I was admitted to the hospital with high-risk multiple myeloma (MM). I’ve been participating in a Phase 2 clinical trial since January 2021, and I was fortunate to achieve minimal residual disease (MRD)-negative status in November 2023 — a milestone that is reached by only 10% of over 20 participants. However, as a side effect of four years of treatment, including Velcade injections (16 total), I’ve developed neuropathy, mainly in my feet. My primary issue is overall numbness and a lack of feeling in my feet. ...

The present breaks the past’s heart

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Change is not my best friend. Not since the day my family moved from Wisconsin to California when I was eight. Leaving the land of my grandmother, the skating rink and snowballs in winter, Lake Mendota and the tennis courts in summer, the community garden and all that seemed unfair. The Fourth of July parade for kids was pure Americana. I dressed as the Statue of Liberty. Ice cream never tasted better than it did then and there. Los Angeles seemed like paradise lost, with a smoggy sky in a child’s eyes. Grown-ups talked about the Manson murders. Take me back, please! That ...

Gabapentin’s benefit to sleep outweighs risks in woman’s case

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DEAR DR. ROACH: I’m a 70 year old woman in good health, other than osteopenia and digestive problems that plague many seniors. I went through a sleep study and was found to have somewhat severe periodic limb movement. I do wake up frequently, always use the bathroom, and can be awake for a while before going back to sleep. I was prescribed 100 mg of gabapentin, which does help. But I worry about dementia since the frequency and length of time of taking gabapentin determines the risk. My watch does indicate a longer, deeper sleep when I take it, but there’s a trade-off. Do I get the ...

Trump is stuck between two realities. Neither serves the American people

Columns

Normally, I worry that events may overtake a column. But not so with the Iran war. I don’t worry about running afoul of a headline or Truth Social post from the president because what is said about the situation is no longer very relevant to the reality. On April 8, Nick Catoggio, my Dispatch colleague, dubbed an earlier stoppage with Iran “Schrodinger’s ceasefire.” This was a reference to the famous thought experiment by the physicist Erwin Schrodinger, who was trying to explain the weirdness of “superpositionality” in quantum physics. A cat in a box is both dead and ...

Dear Annie: When new friends outshine old ones

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Dear Annie: My dearest friend and I go back over 50 years. We’ve seen each other through everything, high and lows. Recently I became disabled and can no longer drive. I’m also a widow. I’m not asking anyone to chauffeur me around (I have that handled), but a phone call here and there would be lovely. She lives just a short distance away, yet she visits only about once a month and texts or calls infrequently. She has never once offered to run an errand. I always tell her how much her visits mean to me. What makes it sting a little more is that friends I’ve known only a ...

Forget the rainbow, let’s taste the vinegar

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My mind wanders, and sometimes I just follow behind it, seeing where it goes. Driving to the gym recently, I debated bringing in my water bottle before remembering there was a water fountain inside. I started thinking about the person who designed the fountain itself, about the mechanics of the water arcing upward at exactly the right angle, about the pressure required to make it work and the decision to replace the old metal push button by the spout with a broad bar easier to press. Someone had to solve those problems so the rest of us could take a drink without giving it a second ...